ESM: Run ESMFold via web interface

Another resource to fold your proteins is ESMFold, which can be accessed in different ways:

• Via the web interface at https://esmatlas.com/resources?action=fold
• Via the ColabFold repository at https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/ESMFold.ipynb
• On the HPC; it is not centrally installed but it is possible to build a virtual environment in which you can run ESMFold. Setting this up is not straightforward though, and thus falls outside the scope of this training session. Feel free to contact jasper.zuallaert [at] vib.be if you would want further instructions on how to do this.

In this exercise, fold a protein of your choice using the web interface of ESMFold (example).

Note that the web interface comes with some disadvantages:

• maximum length of 400
• only single-chain structures can be predicted
• no PAE plots available
• only one prediction at a time